The common side effects in leprosy patients of Nepal due to MDT treatment were jaundice, exfoliative dermatitis and hemolytic anemia. Few patients died due to jaundice, severe anemia and dapsone syndrome. The rare side effects found were agranulocytosis and TEN.
What is the rationale for MDT in leprosy treatment?
Leprosy has been considered a curable disease after the implementation of multidrug therapy (MDT), which has been proven to be safe and effective, by bringing about a significant change in the global and national scenario of leprosy by upgrading the control of leprosy to the next stage of eradication.
What is MDT medicine?
Leprosy. Leprosy is curable with a combination of drugs known as multidrug therapy (MDT), as the treatment of leprosy with only one antileprosy drug (monotherapy) will result in development of drug resistance to that drug.
Why is multiple drug therapy used for tuberculosis?
When two or more drugs to which in vitro susceptibility has been demonstrated are given together, each helps prevent the emergence of tubercle bacilli resistant to the others.
Why rifampicin is given daily in tuberculosis?
Rifampicin plays a key role in tuberculosis (TB) treatment regimens, due to its bactericidal and sterilizing capacity. It was introduced in the early 1970s at a dose of 10 mg/kg (with a maximum of 600 mg) once daily, mainly because of financial considerations and fear of toxicity[1].
What is the full form of MDT?
MDT – Mountain Daylight Time.
Can leprosy be prevented?
How can leprosy be prevented? The best way to prevent the spread of leprosy is the early diagnosis and treatment of people who are infected. For household contacts, immediate and annual examinations are recommended for at least five years after last contact with a person who is infectious.
Is TB medicine harmful?
Some of the potential side effects to be aware of when taking TB medication are: itchy skin. skin rashes, bruising or yellow skin. upset stomach, nausea, vomiting, diarrhoea or loss of appetite.
