In addition, PAX8 has been reported to be useful for the detection and differential diagnosis of ovarian carcinoma. The consistency of PAX8 staining in epithelial ovarian carcinomas (EOCs) and the fallopian tube has provided morphological evidence that EOC may originate from the fallopian tube.
What is PAX8 marker?
PAX8 as an Immunohistochemical Marker for Mesothelioma PAX8 is considered a negative marker for mesothelioma. This means mesothelioma cancer cells usually do not test positive for PAX8. PAX8 is a common marker for kidney cancer, thyroid cancer and cancers of the female reproductive system.
What is high grade serous carcinoma?
High-grade serous carcinoma (HGSC) is a type of tumour that arises from the serous epithelial layer in the abdominopelvic cavity and is mainly found in the ovary. HGSCs make up the majority of ovarian cancer cases and have the lowest survival rates.
What is adenocarcinoma of Mullerian origin?
Adenocarcinoma of Mullerian origin, previously, known as ‘mesothelioma of pelvic origin’, is a rare primary malignancy of the peritoneum [1]. It is frequently found identical to papillary serous adenocarcinoma of the ovary, hence, also referred to as extraovarian peritoneal serous papillary carcinoma.
What does TTF-1 positive mean?
TTF-1 plays a key role in morphogenesis of the lungs[1] and is expressed in up to 90% of pulmonary small cell carcinoma[2]. This explains why this marker is frequently used to search for the primary origin of metastatic neuroendocrine tumours.
How long can you live with serous carcinoma?
Background: Advanced-stage (III/IV) uterine papillary serous carcinoma (UPSC) has a median overall survival (OS) of ~ 3 yrs. The study objective was to determine factors associated with long-term survival in advanced stage UPSC.
What is PAX8 in neoplasm?
PAX8 is a nephric-lineage transcription factor and is a crucial transcription factor for organogenesis of the thyroid gland, kidney, and Müllerian system. PAX8 is shown to be expressed in a high percentage of kidney and ovarian carcinomas. Limited information is known about the specificity of PAX8 in various neoplastic tumors.
Is PAX8 a good marker for thyroid cancer?
PAX8 specificity was confirmed by Western blot analysis, as expression was detected only in ovarian and RCC cell lines. These results show that PAX8 is a highly sensitive marker for thyroid, renal, Müllerian, and thymic tumors.
What is the PAX8 immunohistochemistry test?
PAX8 immunohistochemistry was performed on 1357 tumors (486 tumors in whole-tissue sections and 871 tumors in tissue microarrays, predominantly epithelial) from multiple organs. Only nuclear staining was scored as positive, and tumors were evaluated for the extent and intensity of staining.
What is the function of PAX 8?
PAX 8 is a transcription factor involved in the regulation of organogenesis of the thyroid gland, kidney, and Müllerian system. Recent studies have shown that, among tumors, PAX 8 is commonly expressed in epithelial tumors of the thyroid and parathyroid glands, kidney, thymus, and female genital tra …
