What is a Villin Cre mouse?

Villin-cre transgenic mice have the mouse villin 1 promoter directing expression of Cre recombinase to villus and crypt epithelial cells of the small and large intestines, in a pattern that closely resembles endogenous Vil1 expression. The phenotype of homozygous Vil1-Cre 997 mice is not reported.

What are Cre driver mice?

Cre-driver lines: A special type of transgenic mouse As different neurons have different cellular machinery to activate and express certain genes, Cre-recombinase was targeted to specific neuronal (or other brain cell types) with this in mind.

Are villin-CRE 1000 mice viable?

Villin-cre transgenic mice from founder line 1000 (also called Vil1-Cre 1000, Vil-Cre 1000, Villin-Cre 1000, 12.4KbVilCre 1000 or VCre1000) are viable and fertile as hemizygotes. Homozygous Vil1-Cre 1000 mice are viable but are not healthy and die prematurely.

What is the phenotype of villin-CRE 997 mice?

Villin-cre transgenic mice from founder line 997 (also called Vil1-Cre 997, Vil-Cre 997, Villin-Cre 997, 12.4KbVilCre 997 or VCre997) are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities as hemizygotes. The phenotype of homozygous Vil1-Cre 997 mice is not reported.

What is the function of Villin 1 promoter in villin-CRE transgenic mice?

Villin-cre transgenic mice have the mouse villin 1 promoter directing expression of Cre recombinase to villus and crypt epithelial cells of the small and large intestines, in a pattern that closely resembles endogenous Vil1 expression.

Is there Cre recombinase activity in the gonads of villin-CRE transgenic mice?

Villin-cre transgenic mice from founder line 1000 (Stock No. 021504) are reported to be absent of Cre recombinase activity in gonads. This is in contrast to Villin-cre transgenic mice from founder line 997 (Stock No. 004586) that are reported to have a very low level (<1%) of cells with Cre recombinase activity in the testes.