Malate dehydrogenase (MDH) (EC 1.1.1.37) catalyzes the conversion of oxaloacetate and malate. This reaction is important in cellular metabolism, and it is coupled with easily detectable cofactor oxidation/reduction. It is a rather ubiquitous enzyme, for which several isoforms have been identified, d …
What is the role of malate dehydrogenase in oxaloacetate conversion?
Malate dehydrogenase (MDH) (EC 1.1.1.37) catalyzes the conversion of oxaloacetate and malate. This reaction is important in cellular metabolism, and it is coupled with easily detectable cofactor oxidation/reduction.
What does mitochondrial malate dehydrogenase do in Arabidopsis?
“Mitochondrial malate dehydrogenase lowers leaf respiration and alters photorespiration and plant growth in Arabidopsis.” Cited for: FUNCTION, TISSUE SPECIFICITY. “The plastid-localized NAD-dependent malate dehydrogenase is crucial for energy homeostasis in developing Arabidopsis thaliana seeds.”
What is the role of malate dehydrogenase in Embryo viability?
Essential for embryo viability (PubMed: 24198233, PubMed: 24453164 ). Plays an essential role in heterotrophic metabolism in embryos, and autotrophic metabolism in photosynthetic tissues as well (PubMed: 24453164 ). “Mitochondrial malate dehydrogenase lowers leaf respiration and alters photorespiration and plant growth in Arabidopsis.”
Is malate dehydrogenase a periportal enzyme?
Malate dehydrogenase (MDH) is a predominately periportal enzyme that is expressed highly in the extra-mitochondrial cytoplasm of the liver, although 10% of MDH has been reported in the mitochondria [23]. It is an enzyme in the citric acid cycle that catalyzes the reversible conversion of malate into oxaloacetate.
Does malate dehydrogenase catalyze citric acid cycle?
This reaction is part of many metabolic pathways, including the citric acid cycle. Other malate dehydrogenases, which have other EC numbers and catalyze other reactions oxidizing malate, have qualified names like malate dehydrogenase (NADP+).
Is there an evolutionary linkage between lactate dehydrogenase and malate dehydrogensase?
The amino acid sequences of archaeal MDH are more similar to that of LDH than that of MDH of other organisms. This indicates that there is a possible evolutionary linkage between lactate dehydrogenase and malate dehydrogenase.
