The Stupp protocol has become standard of care for the treatment of glioblastoma (GBM) since its publication in 2005 and has lead to significant survival improvements 1. It consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent.
What is the survival rate for glioblastoma?
Glioblastoma survival The average survival time is 12-18 months – only 25% of glioblastoma patients survive more than one year, and only 5% of patients survive more than five years.
What is the 5 year survival rate for glioblastoma?
Survival rates for more common adult brain and spinal cord tumors
| Type of Tumor | 5-Year Relative Survival Rate | |
|---|---|---|
| Glioblastoma | 22% | 9% |
| Oligodendroglioma | 90% | 82% |
| Anaplastic oligodendroglioma | 76% | 67% |
| Ependymoma/anaplastic ependymoma | 92% | 90% |
How many cycles of temozolomide can you have?
You can have up to 12 cycles of treatment with temozolomide.
How long do side effects of Temodar last?
Fatigue associated with Temodar is usually manageable for most patients. Fatigue may worsen during the week of chemotherapy, but for some patients the fatigue may linger for one week or longer after treatment is completed.
Who is likely to get glioblastoma?
Gliomas are most common in adults between ages 45 and 65 years old. However, a brain tumor can occur at any age.
How long did Ted Kennedy live after being diagnosed with glioblastoma?
Former Massachusetts Sen. Ted Kennedy died of glioblastoma in 2009. Both men survived a little more than a year after diagnosis. The American Cancer Society reports the median length of survival among adults with glioblastoma is 12 to 18 months.
Does temozolomide cause hair loss?
Headache Let your doctor know if you have headaches while having treatment with temozolomide. Tiredness and feeling weak You may feel very tired|. It is important to allow yourself plenty of time to rest. Hair loss This is rare, but your hair may thin, or occasionally fall out completely.
What does the Stupp protocol consist of?
It consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent. According to the original study the Stupp protocol comprises: post-radiotherapy (adjuvant): six cycles consisting of 150-200 mg per square meter for 5 days during each 28-day cycle
What is the Stupp protocol for the treatment of glioblastoma?
This therapy resulted in a significant survival improvement at 2 years: The Stupp protocol is named after Roger Stupp the first author of the 2005 paper, who is a Swiss oncologist from the University of Zürich 1 . 1. Stupp R, Mason WP, van den Bent MJ et-al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.
What is the Stupp protocol for lung cancer treatment?
It consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent. According to the original study the Stupp protocol comprises: post-radiotherapy (adjuvant): six cycles consisting of 150-200 mg per square meter for 5 days during each 28-day cycle This therapy resulted in a significant survival improvement at 2 years:
